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. 2019 Apr 30;17:37. doi: 10.1186/s12915-019-0654-4

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Predictive models for cell line-specific dependence on genes in one-carbon metabolism. Predictive models for RNAi-based dependency scores of MTHFD1 (a), ALDH1L1 (b), SHMT2 (c), and MTHFD1L (d). Significant predictive features of induced cell line-specific dependency are shown for each model (increased expression or copy number in green; decreased expression or copy number in orange)