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. 2019 Apr 29;10:129. doi: 10.1186/s13287-019-1230-0

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 8 — Schematic diagram depicts the therapeutic effects of CS-IGF-1C hydrogel with hP-MSCs for treatments of hindlimb ischemia. In this study, dual BLI was applied for tracking the survival of hP-MSCs by Rluc imaging and the VEGFR2 signal pathway activation by Fluc imaging. When co-transplanted into the hindlimb ischemia model, CS-IGF-1C hydrogel could enhance the survival of hP-MSCs and further promote function recovery of the injured hindlimb by ameliorating angiogenesis and alleviating fibrosis