Fig. 1.

Transcriptional profiling of S2P23 mouse hippocampus. a Amplified RNA from the hippocampus of wild type mice and S2P23 mice was used to perform whole genome expression assay. The expression of TMP21 gene was significantly down-regulated. Values represent mean ± SEM; n = 3, p < 0.05by bead studio analysis. b Protein lysates from the hippocampus of wild type mice and S2P23 mice were resolved on 12% Tris-Glycine SDS-PAGE and endogenous TMP21was detected by T21 antibody. β-actin served as the internal control was detected by mouse anti-actin antibody. The values represent mean ± SEM; n = 3 each group, *p < 0.05 by Student’s t-test. c 1147genes were significantly regulated including667 upregulated genes and 480 downregulated genes. d Chromosome distribution of significantly altered genes in the hippocampus of S2P23 mouse brains. Values represent the percentage of differentially expressed genes on each chromosome at p < 0.05 and ± 1.50-fold cut-off