Skip to main content
. Author manuscript; available in PMC: 2019 Apr 30.
Published in final edited form as: Cell Calcium. 2018 Dec 18;78:35–47. doi: 10.1016/j.ceca.2018.12.008

Fig. 6.

Fig. 6.

Model simulations of SERCA phosphorylation activity effect. Membrane voltage, main membrane currents, AC-cAMP-PKA signaling, and Ca2+ cycling (flux and concentration) in the sarcoplasmic reticulum (SR) in response to different degree of phosphorylation activity. The panels show: (A) the membrane voltage (Vm); (B) cAMP level; (C) PKA activity level; (D) the flux of Ca2+ exiting the sarcoplasmic reticulum (jSRCarel); (E) Ca2+ concentration in the junctional sarcoplasmic reticulum compartment (CajSR); (F) the Na+-Ca2+ exchanger current (INCX); G. funny-current (If); and H. L-type current (ICEL). BDM = 2,3-Butanedione 2-monoxime, BLB = Blebbistatin.