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. 2019 Apr 23;10:386. doi: 10.3389/fphar.2019.00386

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Copyright © 2019 Luo, Bian, Zhang, Xia, Liu, Chen, Ke, Wu and Zhao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Shengui Sansheng San (SSS) extraction ameliorated the CBF deficient area and facilitated arteriogenesis (n = 3). (A,B) MRI imaging at day 7 and quantitative analysis of CBF deficient area. (C) The immunofluorescent staining of α-SMA (red) in ischemic boundary zone were presented (Magnification, ×400), and quantitative analysis of α-SMA expression, vascular density and diameter (D–F). Data presented as mean ± standard deviation. ^∗∗∗p < 0.001 vs. sham group; ^##p < 0.01, ^###p < 0.001 vs. MCAo group; ^&p < 0.05, ^&&p < 0.01, ^&&&p < 0.001 vs. low group; ^xp < 0.05, ^xxp < 0.01, ^xxxp < 0.001 vs. middle group.