Table I.
Demographic, virological and clinical characteristics of HBV-infected patients with HCC and LC.
| Characteristics | All | HCC | LC | P-value |
|---|---|---|---|---|
| Age, years | 51.9±10.6 | 52.8±9.3 | 50.6±12.2 | NS |
| Sex, male/female (%) | 32/41 (78.0%) | 17/23 (73.9) | 15/18 (83.3) | NS |
| Ethnic group (%) | NS | |||
| Kalimantan (Dayak, Banjar, Kutai) | 15.41 (36.6) | 9/23 (39.1) | 6/18 (33.3) | |
| Java | 11/41 (26.8) | 6/23 (8.7) | 5/18 (27.8) | |
| Others (Buton, Sasak, Bugis) | 13/41 (31.7) | 6/23 (26.1) | 7/18 (38.9) | |
| Unknown | 2/41 (4.87) | 2/23 (8.7) | 0/18 (0.0) | |
| Liver function | ||||
| ALT (U/l) | 90.5±89.5 | 104.8±99.8 | 73.7±75.2 | NS |
| AST (U/l) | 178.0±189.6 | 243.7±237.0 | 105.0±55.7 | <0.05 |
| AFP, ng/ml (%) | NS | |||
| ≥200 | 16/41 (39.0) | 11/23 (47.8) | 5/18 (27.8) | |
| ≤200 | 10/41 (24.4) | 3/23 (13.0) | 7/18 (38.9) | |
| Unknown | 15/41 (36.6) | 9/23 (39.1) | 6/18 (33.3) | |
| HBsAg (R-PHA) (%) | NS | |||
| Positive | 33/41 (80.5) | 18/23 (78.3) | 15/18 (83.3) | |
| Negative | 5/41 (12.2) | 3/23 (13.0) | 2/18 (11.1) | |
| Unknown | 3/41 (7.3) | 2/23 (8.7) | 1/18 (5.5) | |
| HBeAg (EIA) (%) | NS | |||
| Positive | 3/41 (7.3) | 2/23 (8.7) | 1/18 (5.6) | |
| Negative | 38/41 (92.7) | 21/23 (91.3) | 17/18 (94.4) | |
| Quantitative HBV DNA (log copies/ml) | 6.1±2.4 | 5.2±2.6 | 7.3±1.4 | NS |
| HBV DNA, positive samples (%) | ||||
| Pre-S region | 41/41 (100.0) | 23/23 (100.0) | 18/18 (100.0) | NS |
| X region | 38/41 (92.7) | 21/23 (91.3) | 17/18 (94.4) | NS |
| Core region | 40/41 (97.6) | 22/23 (95.6) | 18/18 (100.0) | NS |
| Subgenotype (Pre-S) (%) | NS | |||
| B3 | 35/41 (85.4) | 21/23 (91.3) | 14/18 (77.8) | |
| C1 | 6/41 (14.6) | 2/23 (8.7) | 4/18 (22.2) |
Data concerning age, ALT and AST levels are presented as mean ± standard deviation. HBV, hepatitis B virus; HCC, hepatocellular carcinoma; LC, liver cirrhosis; AFP, α-fetoprotein; ALT, alanine transferase; AST, aspartate transaminase; HBsAg, Hepatitis B surface antigen; R-PHA, reversed passive hemagglutination; HBeAg, hepatitis B e-antigen; EIA, enzyme immunoassay; NS, not significant. Statistical analysis was performed using χ2 test or Fisher's exact test for categorical variables. t-tests were used for continuous variables.