Table III.
HBV mutations in patients with ALD and HBV carriers.
| Mutations | ALD (%) | HBV carriers (%) | P-value |
|---|---|---|---|
| X region | |||
| C1495T | 0/38 (0.0) | 0/46 (0.0) | NS |
| C1505A | 11/38 (28.9) | 0/46 (0.0) | <0.05 |
| T1631C | 21/38 (55.3) | 22/46 (47.8) | NS |
| C1638T | 17/38 (44.7) | 13/46 (28.3) | NS |
| C1726A | 5/36 (13.9) | 11/46 (23.9) | NS |
| BCP region | |||
| T1753V | 14/35(40) | 0/46 (0.0) | <0.05 |
| A1762T/G1764A | 25/34 (73.5) | 0/46 (0.0) | <0.05 |
| T1768A | 0/34 (0.0) | 5/46 (10.9) | NS |
| PC region | |||
| C1858T | 6/34 (17.6) | 0/46 (0.0) | <0.05 |
| G1896A | 12/34 (35.3) | 29/46 (63.0) | <0.05 |
| G1899A | 11/34 (32.3) | 6/46 (13.0) | NS |
| Core region | |||
| G1915T | 1/33 (3.0) | 0/46 (0.0) | NS |
NS, not significant; BCP, basal core promoter; PC, precore. Statistical analysis was performed using χ2 test or Fisher's exact test for categorical variables. Out of 41 patients with advanced liver disease, the total number in each gene region indicates the number of patients whose strains were successfully sequenced.