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. 2019 Apr 10;11:2963–2976. doi: 10.2147/CMAR.S202664

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© 2019 Han et al.

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).

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Meta-analysis of the differential expression of E2F1 and E2F3, and the Kaplan–Meier survival curves of E2F1, E2F3, and miR-34a in HCC. Meta-analysis for the differential expression of E2F1 (A) and E2F3 (B) in primary HCC tissues (N cases) compared to normal tissues (N control), respectively, with a random-effects model (CI; I-squared measures the degree of heterogeneity in meta-analyses). HCC patients with either high E2F1 (C), or high E2F3 (D), or low miR-34a (E) had an inferior overall survival compared to those with either low E2F1, or low E2F3, or high miR-34a, respectively.

Abbreviation: HCC, hepatocellular carcinoma.