Table 5.
Analysis of haplotypes and their association with dose
| Haplotype | rs9923231 | rs61742245 | rs9934438 | rs8050894 | rs2359612 | rs7294 | F (%) | Difference in mean (CI)* |
P |
|---|---|---|---|---|---|---|---|---|---|
| H1 | A | G | T | C | T | G | 50 | 0.00 | – |
| H2 | G | G | C | G | C | A | 32 | 2.29 (1.6–2.95) |
<0.0001** |
| H3 | G | G | C | G | C | G | 11 | 1.87 (0.93–2.81) |
0.00015** |
| H4 | G | T | C | G | C | G | 2 | 3.18 (1.9–4.46) |
<0.0001** |
| H5 | G | G | C | G | T | G | 1.2 | 1.02 (−1.61–3.65) |
0.45 |
| Rare | * | * | * | * | * | * | 2.8 | 2.36 (0.62–4.1) |
0.0089** |
Notes: *The most frequent haplotype is considered the reference and the difference in means measures the difference between the mean of dose among each haplotype and the reference. **Significant association.