. 2019 Apr 12;11:2987–2995. doi: 10.2147/CMAR.S191105

Table 2.

Subgroup analyses by molecular subtype based on transcriptome for CD3D and CD3D/CD4 in MIBC (TCGA, n=406)

Molecular subtype	CD3D^a				CD3D/CD4^a
Molecular subtype	Univariate		Multivariate^b		Univariate		Multivariate^b
Beta	P	Beta	P	Beta	P	Beta	P
Luminal papillary (n=135)	−0.19	0.12	−0.09	0.45	−0.51	0.5	0.08	0.92
Luminal infiltrated (n=76)	−0.33	0.035*	−0.24	0.14	−2.25	0.09	−1.54	0.29
Luminal (n=43)	−0.21	0.37	−0.31	0.25	−1.64	0.27	−2.75	0.15
Basal squamous (n=133)	−0.37	0.00059*	−0.38	0.00065*	−4.8	6.09E-07*	−4.73	2.67E-06*
Neuronal (n=19)	−0.06	0.8	−0.11	0.72	0.088	0.95	−0.59	0.74

Notes: ^aGene expression measured as log2 RSEM, or derived ratio, as continuous variable. ^bMultivariate Cox regression adjusted by age, gender and tumor stage. *Statistically significant.

Abbrevaiton: TCGA, the Cancer Genome Atlas.