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. 2019 Apr 11;11:2997–3007. doi: 10.2147/CMAR.S199368

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© 2019 Zhu et al.

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BCL11A promotes tumor metastasis, cancer cell migration, and the stemness of breast cancer cells. BCL11A promotes cell metastasis ability, confirmed by Transwell invasion assay in vitro. (A) Representative invaded cells image (Left), and the statistical analysis of the invaded cell number (Right) are shown. All the data was shown as the mean ± SD, and three independent experiments were performed (**p<0.01; *p<0.05). (B) Representative image of lung metastasis nodules on the lung of xenograft model (arrows). 8 weeks after tail vein injection of BCL11A-modulating MDA-MB-231 and MCF-7 cells, the number of lung nodules on lungs surface of nude mice was counted and analysed (N=3) (**p<0.01; *p<0.05). (C) Hematoxylin and eosin stained metastatic nodules on the surface of the lung. Representative image of sections was shown. Original magnification, 100×. (D) BCL11A increases the sphere-forming ability of MDA-MB-231 and MCF-7 cells. Original magnification: ×100. (E) Representative dot plots of CD44+/CD24− cell surface markers from mammospheres in BCL11A-osverexpressing MCF-7 and sh-BCL11A MDA-MB-231 and their controls.