Table 3.
Results of univariate and multivariate cox regression analyses for CSS, OS and PFS before propensity score matching
| Characteristics | CSS | OS | PFS | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Univariate | Multivariate | Univariate | Multivariate | Univariate | Multivariate | |||||||
| P-value | HR (95% CI) | P-value | HR (95% CI) | P-value | HR (95% CI) | P-value | HR (95% CI) | P-value | HR (95% CI) | P-value | HR (95% CI) | |
| Aged > 65 years | 0.069 | 1.337 (0.978–1.829) | 0.063 | 1.417 (0.982–2.047) | 0.001 | 1.583 (1.206–2.079) | 0.001 | 1.677 (1.222–2.302) | 0.142 | 1.185 (0.945–1.485) | ||
| Gender (male) | <0.001 | 1.763 (1.320–2.354) | <0.001 | 1.884 (1.355–2.621) | <0.001 | 1.539 (1.208–1.960) | 0.003 | 1.516 (1.151–1.997) | 0.015 | 1.297 (1.051–1.600) | 0.009 | 1.340 (1.076–1.670) |
| BMI | 0.007 | 0.943 (0.904–0.984) | 0.073 | 0.957 (0.913–1.004) | 0.023 | 0.960 (0.926–0.994) | 0.078 | 0.965 (0.928–1.004) | 0.037 | 0.968 (0.938–0.998) | 0.048 | 0.968 (0.938–1.000) |
| Diabetes | 0.937 | 1.016 (0.690–1.496) | 0.814 | 1.040 (0.751–1.439) | 0.604 | 1.077 (0.813–1.429) | ||||||
| Hypertension | 0.152 | 1.239 (0.924–1.662) | 0.012 | 1.369 (1.070–1.750) | 0.860 | 1.020 (0.819–1.270) | ||||||
| Coronary disease | 0.164 | 0.702 (0.426–1.156) | 0.989 | 1.003 (0.696–1.445) | 0.937 | 1.013 (0.730–1.406) | ||||||
| Alcohol | 0.852 | 0.957 (0.602–1.521) | 0.649 | 1.090 (0.753–1.577) | 0.248 | 0.810 (0.566–1.159 ) | ||||||
| Tobacco | 0.189 | 1.273 (0.888–1.824) | 0.054 | 1.339 (0.994–1.802) | 0.823 | 0.968 (0.726–1.291) | ||||||
| Hydronephrosis | 0.139 | 1.252 (0.930–1.687) | 0.048 | 1.394 (1.004–1.937) | 0.178 | 1.186 (0.925–1.521) | 0.003 | 1.611 (1.170–2.218) | 0.040 | 1.261 (1.011–1.572) | 0.023 | 1.296 (1.036–1.620) |
| AST/ALT ≥1.23 | <0.001 | 2.339 (1.642–3.331) | <0.001 | 2.599 (1.725–3.913) | <0.001 | 1.925 (1.454–2.548) | <0.001 | 1.842 (1.337–2.540) | <0.001 | 1.726 (1.360–2.190) | 0.001 | 1.454 (1.157–1.828) |
| Tumor location (pelvis) | 0.809 | 0.986 (0.878–1.106) | 0.056 | 1.271 (0.994–1.626) | 0.012 | 1.509 (1.095–2.081) | 0.247 | 0.883 (0.715–1.090) | ||||
| T Stage (≥3) | <0.001 | 3.118 (2.339–4.156) | <0.001 | 2.482 (1.763–3.494) | <0.001 | 2.391 (1.876–3.049) | <0.001 | 2.098 (1.571–2.803) | 0.002 | 1.418 (1.139–1.765) | 0.029 | 1.319 (1.029–1.691) |
| Tumor size (>5cm) | <0.001 | 2.968 (2.114–4.168) | <0.001 | 2.015 (1.391–2.917) | <0.001 | 2.595 (1.911–3.523) | <0.001 | 1.916 (1.374–2.670) | 0.002 | 1.602 (1.195–2.416) | 0.030 | 1.411 (1.034–1.924) |
| N Stage (≥1) | <0.001 | 3.217 (2.176–4.758) | 0.001 | 2.084 (1.345–3.229) | <0.001 | 2.606 (1.817–3.739) | 0.002 | 1.873 (1.255–2.794) | 0.067 | 1.404 (0.976–2.020) | ||
| Cellular grade (≥3) | <0.001 | 1.993 (1.492–2.663) | <0.001 | 1.768 (1.388–2.252) | 0.072 | 1.213 (0.983–1.497) | ||||||
| Lymphatic microvascular invasion | 0.039 | 1.781 (1.031–3.077) | 0.297 | 1.321 (0.783–2.226) | 0.218 | 1.312 (0.851–2.022) | ||||||
| Tumor necrosis | 0.055 | 1.467 (0.992–2.170) | 0.093 | 1.343 (0.952–1.894) | 0.339 | 1.162 (0.854–1.581) | ||||||
| Tumor hemorrhage | 0.016 | 2.049 (1.141–3.679) | 0.010 | 2.273 (1.219–4.239) | 0.017 | 1.849 (1.115–3.067) | 0.004 | 2.197 (1.286–3.754) | 0.340 | 1.286 (0.766–2.158) | ||
| Tumor architecture (sessile) | 0.001 | 1.755 (1.271–2.423) | <0.001 | 1.703 (1.286–2.254) | 0.110 | 1.234 (0.953–1.597) | ||||||
| Squamous metaplasia | 0.022 | 1.652 (1.075–2.539) | 0.016 | 1.590 (1.091–2.316) | 0.793 | 1.049 (0.736–1.495) | ||||||
| Sarcomatoid differentiation | 0.008 | 2.219 (1.236–3.984) | 0.004 | 2.121 (1.279–3.518) | 0.715 | 1.105 (0.647–1.886) | ||||||
| Glandular differentiation | 0.064 | 1.221 (0.988–1.508) | 0.011 | 2.317 (1.210–4.439) | 0.036 | 1.228 (1.013–1.489) | 0.003 | 2.388 (1.355–4.208) | 0.749 | 1.042 (0.809–1.343) | ||
| Laparoscopy | 0.032 | 0.678 (0.476–0.967) | 0.143 | 0.802 (0.598–1.077) | 0.361 | 0.890 (0.693–1.143) | ||||||
Abbreviations: BMI, body mass index; CSS, cancer-specific survival; OS, overall survival; PFS, progression-free survival.