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. 2019 Apr 10;13:1145–1153. doi: 10.2147/DDDT.S196319

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© 2019 Chen et al.

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).

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Combination of emodin with PTX-induced apoptosis in tumor tissues via inhibition of Akt signaling pathway in vivo. (A) TUNEL staining of tumor tissues in each group. Quantification of TUNEL positive cells in tissues. (B) Expressions of p-Akt and active caspase 3 were analyzed by Western blotting in A549 cells. (C) Relative expression of p-Akt was quantified by normalizing to Akt. (D) Relative expression of active caspase 3 was quantified by normalizing to β-actin. **P< 0.01 compared with vehicle group; ^#P< 0.05, ^##P< 0.01 compared with 10 mg/kg PTX group. Each group performed at least three independent experiments.

Abbreviation: PTX, paclitaxel.