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Future therapies in development. ANGPTL3: angiopoietin-like 3; apo: apolipoprotein; Lp(a): lipoprotein(a); siRNA: small interfering RNA
| AGENT | MECHANISM OF ACTION | PRIMARY LIPID COMPONENT TARGET |
|---|---|---|
| Inclisiran (ALN-PCSsc) | siRNA to PCSK9 | LDL-C |
| Bempedoic acid (ETC-1002) | Inhibition of ATP citrate lyase | LDL-C |
| AKCEA-APO(a)-LRX | Antisense to apo(a) | Lp(a) |
| AKCEA-APOCIII-LRX | Antisense to apoCIII | Triglycerides |
| Evinacumab | Human monoclonal antibody to ANGPTL3 | Triglycerides and cholesterol |
