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. 2019 Apr 11;12:2789–2798. doi: 10.2147/OTT.S196150

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© 2019 Yang et al.

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STC1 in the microenvironment activates Akt by enhancing the phosphorylation at Ser473. (A) Treatment with rhSTC1 upregulated the phosphorylation of Akt at Ser473. (B) Treatment with STC1Ab inhibited the phosphorylation of Akt at Ser473. (C) Treatment with LY294002 inhibited STC1-stimulated metastasis. (D) Quantification of metastasis by counting the number of migrated cells. Data were presented as mean ± SEM from at least three independent experiments. (E) Schematic model of microenvironmental STC1-mediated metastasis in ovarian cancer.