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. 2019 Apr 11;11:3111–3123. doi: 10.2147/CMAR.S200566

Figure 8.

Figure 8

miR-665 decreases HMGB1 to inhibit RB cell growth in vivo via the Wnt/β-catenin pathway. (A) The volume of tumor xenografts was measured every 2 days. The growth of the tumor xenografts in the miR-665 mimics group was notably slower than that in the miR-NC group. *P<0.05 compared with miR-NC. (B) Representative images of tumor xenografts excised from nude mice obtained 4 weeks after subcutaneous injection of Y79 cells transfected with miR-665 mimics or miR-NC. (C) All nude mice were sacrificed 30 days after injection, and the tumor xenografts were excised. The weight of the tumor xenografts in the miR-665 group was notably lower than that in the miR-NC group. *P<0.05 compared with miR-NC. (D) miR-665 expression in the tumor xenografts was analyzed by RT-qPCR. *P<0.05 compared with miR-NC. (E) The expression levels of HMGB1 and the central members of the Wnt/β-catenin pathway (p-β-catenin, β-catenin, and cyclin D1) were detected by Western blot analysis.