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. 2019 Apr 12;12:1201–1216. doi: 10.2147/JPR.S188758

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© 2019 Yin et al.

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).

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The CPIP rat model exhibits persistent mechanical and thermal hyperalgesia. (A) Representative photographs of rat hind paw taken during CPIP model establishment, 10 minutes and 7 days after model establishment. The red arrow indicates the O ring clamped right above the ankle. (B) Thickness evaluation of ipsilateral hind paws of CPIP and Sham group rats. (C) Paw withdraw latency of ipsilateral hind paws of Sham and CPIP group rats. (D) 50% paw withdraw threshold of ipsilateral hind paw of Sham and CPIP group rats. N=6 rats/group. *P<0.05 and **P<0.01 vs Sham group.

Abbreviation: CPIP, chronic post-ischemic pasin.