Table 2.
Correlations of FOXP1 and FOXO3a protein expression with the clinicopathological characteristics of EHCC
| CPC | Case No. | FOXP1 | FOXO3a | ||||
|---|---|---|---|---|---|---|---|
| Pos No. (%) | χ 2 | P-value | Pos No. (%) | χ 2 | P-value | ||
| Age (year) | |||||||
| ≤45 years | 17 | 10 (58.8) | 2.092 | 0.148 | 10 (58.8) | 1.356 | 0.244 |
| ＞45 years | 83 | 33 (39.8) | 36 (43.4) | ||||
| Sex | |||||||
| Male | 61 | 26 (42.6) | 0.009 | 0.924 | 30 (49.2) | 0.637 | 0.425 |
| Female | 39 | 17 (43.6) | 16 (41.0) | ||||
| Differentiation | |||||||
| Well | 31 | 21 (67.7) | 15.314 | 0.000 | 20 (64.5) | 8.574 | 0.014 |
| Moderately | 34 | 15 (44.1) | 16 (47.1) | ||||
| Poorly | 35 | 7 (20.0) | 10 (28.6) | ||||
| Tumor size | |||||||
| ≤3cm | 62 | 30 (58.4) | 1.932 | 0.165 | 32 (51.6) | 2.069 | 0.150 |
| ＞3cm | 38 | 13 (34.2) | 14 (36.8) | ||||
| Tumor position | |||||||
| Hilar site | 27 | 11 (40.7) | 0.690 | 0.708 | 8 (29.6) | 3.998 | 0.136 |
| Hepatic duct | 4 | 1 (25.0) | 2 (50.0) | ||||
| Distal duct | 69 | 31 (44.9) | 36 (52.2) | ||||
| Biliary stone | |||||||
| No | 69 | 35 (50.7) | 5.419 | 0.020 | 33 (47.8) | 0.299 | 0.585 |
| Yes | 31 | 8 (25.8) | 13 (41.9) | ||||
| Lymph node metastasis | |||||||
| No | 62 | 38 (61.3) | 22.269 | 0.000 | 37 (59.7) | 12.288 | 0.000 |
| Yes | 38 | 5 (13.2) | 9 (23.7) | ||||
| Invasion | |||||||
| No | 33 | 23 (69.7) | 14.323 | 0.000 | 22 (66.7) | 8.469 | 0.004 |
| Yes | 67 | 20 (29.9) | 24 (35.8) | ||||
| TNM stage | |||||||
| I+II | 35 | 27 (77.1) | 29.046 | 0.000 | 24 (68.6) | 12.210 | 0.002 |
| III | 38 | 13 (34.2) | 15 (39.5) | ||||
| IV | 27 | 3 (11.1) | 7 (25.9) | ||||
| Surgery | |||||||
| Radical | 54 | 34 (63.0) | 19.655 | 0.000 | 35 (64.8) | 16.808 | 0.000 |
| Palliative | 36 | 6 (16.9) | 9 (25.0) | ||||
| Biopsy | 10 | 3 (30.0) | 2 (20.0) | ||||
Abbreviations: CPC, clinicopathological characteristics; EHCC, extrahepatic cholangiocarcinoma; Pos, positive.