Table 5.
Univariate and multivariate Cox regression analyses of PLA2G5 expression and clinicopathological features in affecting the OS of patients with HGG
| Variables | Univariate | Multivariate | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P | HR | 95% CI | P | |
| Gender | 0.851 | 0.700–1.034 | 0.105 | 0.895 | 0.735–1.091 | 0.272 |
| Age | 1.862 | 1.534–2.260 | <0.001 | 1.761 | 1.447–2.144 | <0.001 |
| Chemotherapy | 0.581 | 0.481–0.703 | <0.001 | 0.639 | 0.517–0.790 | <0.001 |
| Radiotherapy | 0.537 | 0.444–0.649 | <0.001 | 0.702 | 0.567–0.868 | 0.001 |
| IDH1 mutation | 0.308 | 0.164–0.577 | <0.001 | 0.345 | 0.182–0.653 | 0.001 |
| PLA2G5 expression | 1.360 | 1.122–1.649 | 0.002 | 1.258 | 1.032–1.533 | 0.023 |
Abbreviations: HR, hazard ratio; CI, confidence interval; HGG, high-grade glioma; IDH1, isocitrate dehydrogenase 1; OS, overall survival.