Figure 1. Mode of action for miRs-26-5p, -150, -330-3p, -378, -490-3p, -616 and -661. These miRs are up-regulated in NSCLC tissues in comparison to matching normal tissues. The pro-metastatic pathways activated by these miRs are indicated. β8: Integrin β8, FOXO4: forkhead-box-protein 4, GRIA3: glutamate ionotropic receptor AMPA 3, HMOX1: hemoxygenase 1, JAK2: Janus kinase 2, PCBP1: poly(rc)-binding protein 1, PRL3: phosphatase of regenerating liver 3, Rb1: retinoblastoma protein 1, RbX: ring-box protein 1, SOX7: sry-box transcription factor 7, STAT3: signal transducer and activator of transcription 3.