Figure 3. miR-128-3p mode of action. miR-128b is up-regulated in NSCLC samples compared to matching normal tissues. miR-128-3p activates Wnt/β- catenin and TGFβ signaling, resulting in pro-metastatic activity. Axin 1: WNT pathway inhibitor, cPP1: dual specificity protein tyrosine phosphatase 1. CSC: cancer stem cell, EMT: epithelial mesenchymal transition, SFRP2: secreted frizzled-related protein 2, SMURF2: smad ubiquitin regulatory factor 2, TGFβ: transforming growth factor β, WIF-1: WNT inhibitory factor 1, WNT: wingless-type MMTV integration site family member.