Figure 7. miRs-361-3p, -622, -876-5p and 1207-5p: mode of action. These miRs are down-regulated in NSCLC specimens compared to matching normal tissues. The pro-metastatic pathways activated due to their down-regulation are shown. AKT: Serine-threonine kinase AKT, CSF1: colony stimulating factor 1, CSFR1: colony stimulating factor receptor 1, BMP4: bone morphogenetic protein 4, EMT: epithelial mesenchymal transition, HIF-1 alpha: hypoxia inducible factor 1 alpha, JAK1,2: Janus kinase 1,2, M2 TAMS: M2 tumor-associated macrophages, RAC1: Ras-related C3 botulinum toxin substrate 1, SH2B1: SH2B adaptor protein 1.