Figure 8. miRs-22, -101, -200c and -338: mode action These miRs are down-regulated in NSCLC samples compared to matching normal tissues. Their down-regulation results in activation of pro-metastatic pathways shown here. ACLY: ATP citrate lyase, β3: integrin-β3, EMT: epithelial mesenchymal transition, NfkappaB: nuclear factor kappa B, SOX4: SRY-related HMG-box4, TRAF5,6: TNF receptor associated factor 5,6, USP25: ubiquitin specific lyase peptidase 25, ZEB1: Zinc finger E-box binding homeobox 1.