Figure 9. miRs-29c, 95-3p, -145-5p and -708-5p: mode of action. These miRs are down-regulated in NSCLC compared to matching normal tissues. Their down-regulation results in the activation of pro-metastatic pathways as shown here. β1: Integrin-β1, CSP3: caspase 3, EGFR: epidermal growth factor receptor, MMP2: matrix metalloproteinase 2, MYC: transcription factor MYC, Oct 4: octamer-binding transcription factor 4, p21: protein 21, ROCK2: Rho-associated coiled-coil containing protein kinase 2, TPD52: tumor protein D52, TSP1: Thrombospondin 1.