Table 1.
Baseline Demographic Characteristics and Clinical Parameters of the FIND and AA-DHS Cohorts
| Variable | Cases With DKD |
Controls Without Nephropathy |
||||
|---|---|---|---|---|---|---|
| AA-DHS (n = 61) | FIND (n = 87) | P Value | AA-DHS (n = 69) | FIND (n = 118) | P Value | |
| Without diabetes, % | 0 | 0 | 0 | 15 (n = 18) | 0.0002 | |
| Female sex, n (%) | 37 (61) | 55 (63) | 0.86 | 49 (71) | 78 (66) | 0.52 |
| Age at enrollment, y | 58 (51–66) | 62 (55–70) | 0.049 | 52 (48–58) | 58 (51–66) | 0.0003 |
| Diabetes duration, y | 13 (9–20) | 20 (14–25) | 0.0006 | 8 (6–12) | 11 (2–18) | 0.89 |
| CKD-EPI eGFR, mL/min/1.73m2 | 54 (45–86) | 48 (32–57) | 0.0014 | 117 (113–122) | 93 (79–113) | < 0.0001 |
| UACR, mg/g | 362 (47–917) | 49 (14–126) | <0.0001 | 5.9 (4.0–11.0) | 1.0 (0.3–2.7) | < 0.0001 |
| Hemoglobin A1c, % | 8.7 (7.6–10.2) | 7.4 (6.4–9.5) | 0.0069 | 7.7 (6.6–8.8) | 6.9 (5.9–8.5) | 0.0091 |
| APOL1 2 RRVs, n/N (%) | 10/59 (17) | 9/55 (16) | >0.99 | 6/68 (9) | 7/80 (9) | > 0.99 |
| Log (JC titers)a | 10.4 (9.3–16.2) | 12.1 (9.2–15.3) | 0.98 | 13.1 (11.1–13.7) | 14.3 (11.0–16.4) | 0.073 |
| JC virus, % | 26.2 | 32.2 | 0.47 | 30.4 | 46.6 | 0.032 |
| Log (BK titers)a | 5.1 (4.6–7.1) | 5.3 (4.3–6.4) | 0.98 | 6.7 (4.8–8.8) | 6.2 (5.0–8.2) | 0.93 |
| BK virus, % | 18.0 | 16.1 | 0.83 | 23.2 | 21.2 | 0.85 |
Data presented as median (25th percentile to 75th percentile) for continuous variables or % for categorical variables (continuous data were analyzed using Wilcoxon two-sample test and categorical data using Fisher exact test).
Abbreviation: CKD-EPI, Chronic Kidney Disease Epidemiology Collaboration.
a
Data from subjects with virus present.