Table 3.
Differences in Annual eGFR Decline and OR of Incident CKD per 5 ng/mL Higher Plasma 25(OH)D and According to DBP Genotype and Diabetes Status
| Interactions With 25(OH)D |
eGFR Decline
|
Incident CKD
|
||||
|---|---|---|---|---|---|---|
| No. Included (% of JHS) | Difference in Annual eGFR Decline in mL/min/1.73 m2/y (95% Cl) a | P-Interaction Value | No. of Events/No. Included | OR of Incident CKD (95% CI) | P-Interaction Value | |
| DBP genotypeb | ||||||
| rs4588 (overall) | 1181 | −0.05 (−0.14 to 0.03) | 0.467 | 118/983 | 0.97 (0.82 to 1.14) | 0.310 |
| AA/AC | 201 | 0.01 (−0.19 to 0.22) | 16/173 | 1.18 (0.78 to 1.79) | ||
| CC | 980 | −0.07 (−0.16 to 0.03) | 102/810 | 0.94 (0.78 to 1.12) | ||
| rs7041 (overall) | 1171 | −0.06 (−0.14 to 0.03) | 0.303 | 117/979 | NA | 0.005 |
| GG/GT | 349 | −0.12 (−0.28 to 0.03) | 46/293 | 0.69 (0.51 to 0.93) | ||
| TT | 828 | −0.03 (−0.13 to 0.07) | 71/686 | 1.13 (0.93 to 1.37) | ||
| Diabetes mellitus | ||||||
| Overall | 2138 | NAc | <0.001 | 220/1803 | 0.94 (0.83 to 1.06) | 0.60 |
| No diabetes | 1736 | 0.01 (−0.06 to 0.07) | 145/1517 | 0.96 (0.83 to 1.10) | ||
| Diabetes | 402 | −0.27 (−0.41 to −0.31) | 75/286 | 0.90 (0.71 to 1.12) | ||
All models adjusted for age, sex, income, occupation, smoking, physical activity score, diet quality score, BMI, diabetes, systolic blood pressure, baseline eGFR, and ACR (for the eGFR decline model); estimates are per 5 ng/mL higher plasma 25(OH)D. Positive slope represents faster eGFR decline.
Negative difference represents slower eGFR decline.
DBP genotype nomenclature rs4588 and rs7041 are labeled in accordance with their most common designation in the literature; however, the 1000 Genomes platform from which they were imputed labeled the alleles as G/T for rs4588 and A/C for rs7041.
Overall effects not reported due to significant interactions.