Table 2.

Clinical characteristics at the time of hospital admission according to presence or absence of elevated Lp(a) and FH phenotype

Variable	Lp(a) ≥0.5 g/L	Lp(a) <0.5 g/L	p Value	FH+	FH–	p Value
Age, y	58.7 ± 12.5	61.8 ± 13.9	0.075	56.4 ± 10.6	61.6 ± 13.9	0.028
Male sex	59.0	73.8	0.012	61.1	71.0	0.225
HTN	49.4	52.8	0.595	55.6	51.3	0.627
T2DM	28.9	30.9	0.736	44.4	28.3	0.047
Ever smoked	36.1	40.8	0.459	41.7	39.4	0.796
Statin at admission	42.7	36.8	0.346	80.6	32.6	<0.001
Cr, μmol/L, median (IQR)	76.6 (72.3–81.0)	81.7 (78.0–85.5)	0.128	85.1 (75.5–95.9)	79.7 (76.6–82.9)	0.266
TC, mmol/L	5.1 ± 1.4	4.8 ± 1.4	0.044	5.9 ± 1.4	4.7 ± 1.2	<0.001
HDL‐C, mmol/L	1.1 ± 0.3	1.0 ± 0.3	0.067	1.0 ± 0.2	1.1 ± 0.3	0.733
TG, mmol/L, median (IQR)	1.5 (1.4–1.7)	1.6 (1.5–1.7)	0.605	2.0 (1.6–2.4)	1.5 (1.4–1.6)	0.015
LDL‐C, mmol/L	3.2 ± 1.2	2.9 ± 1.1	0.011	3.9 ± 1.2	2.9 ± 1.0	<0.001
Adjusted LDL‐C, mmol/La	3.7 ± 2.3	3.5 ± 1.2	0.149	6.7 ± 2.0	3.1 ± 0.92	<0.001
Non–HDL‐C, mmol/L	4.0 ± 1.4	3.7 ± 1.3	0.099	4.8 ± 1.4	3.6 ± 1.2	<0.001
LDL‐C, mmol/L
>1.8	90.4	80.2	0.035	100	80.6	0.004
>2.5	30.1	36.6	0.285	91.7	61.6	<0.001
Lp(a), g/Lb	0.85 (0.79‐0.92)	0.13 (0.12‐0.14)	<0.001	0.28 (0.19‐0.41)	0.20 (0.18‐0.22)	0.062

Abbreviations: CI, confidence interval; Cr, creatinine; FH, familial hypercholesterolemia; HDL‐C, high‐density lipoprotein cholesterol; HTN, hypertension; IQR, interquartile range; LDL‐C, low‐density lipoprotein cholesterol; Lp(a), lipoprotein(a); SD, standard deviation; T2DM, type 2 diabetes mellitus; TC, total cholesterol; TG, triglycerides.

Data are presented as percentages or mean ± SD, unless otherwise noted.

^aLDL‐C adjusted for statin therapy and the cholesterol content of Lp(a).

^bData presented as the geometric mean and 95% CI.