Table 1.
Summary of the final list of AD drugs and their known target genes
| Drug Name |
TTD PharmGKB |
Drug Status | Known drug target genes | Mode Value of Degrees | Average Value of Degrees | ||||
|---|---|---|---|---|---|---|---|---|---|
| Degree 1 | Degree 2 | Degree 3 | Degree 4 | Degree 5 | |||||
| Donepezil |
DAP000560 PA449394 |
Approved | ACHE | NaN | HTR2A | NaN | NaN | 1, 3 | 2 |
| Rivastigmine |
DAP000149 PA451262 |
Approved | ACHE, BCHE | NaN | NaN | NaN | NaN | 1 | 1 |
| Memantine |
DAP000493 PA10364 |
Approved | NaN | NaN | GRIN3A, GRIN2A, GRIN2B, HTR3A, CHRNA7, DRD2, GRIN1 | NaN | NaN | 3 | 3 |
| Galantamine |
DAP000559 PA449726 |
Approved | CHRNA4, CHRNA7, CHRNB2, ACHE, BCHE | NaN | CHRNA1, CHRNB1, CHRNA2, CHRNA3, CHRNA5, CHRNA6, CHRNB3, CHRNB4 | NaN | CHRND, CHRNG | 3 | 3 |
| Tacrine |
DAP000558 PA451576 |
Approved | NaN | NaN | ACHE, BCHE | NaN | NaN | 3 | 3 |
| Rosiglitazone |
DCL000633 PA451283 |
Phase III | PPARG | NaN | NaN | NaN | NaN | 1 | 1 |
The nodes directly linked with a certain drug according to the relationships of PharmGKB are defined as degree 1. The nodes linked with this drug through degree 1 are defined as degree 2. Degree 3, degree 4, and degree 5 are defined by similar way. NaN means that the known drug target gene is not in this degree. “Mode value of degrees” means that most of the known drug target genes are found in this degree.