Table 2.
Summary of the 18 potential AD drug target genes identified in this study
| Gene symbol | Protein name | Gene ID | P‐value | Reported or NOT |
|---|---|---|---|---|
| RELN | Reelin | 5649 | 0.000546 | Reported |
| DNMBP | Dynamin binding protein | 23268 | 0.003415 | Reported |
| APOD | Apolipoprotein D | 347 | 0.003759 | Reported |
| LEP | Leptin | 3952 | 0.008264 | Reported |
| HLA‐B | Major histocompatibility complex, class I, B | 3106 | 0.011278 | Reported |
| C1QB | Complement C1q B chain | 713 | 0.015038 | Reported |
| HSPG2 | Heparan sulfate proteoglycan 2 | 3339 | 0.018797 | Reported |
| MTTP | Microsomal triglyceride transfer protein | 4547 | 0.022556 | NOT |
| IL−10 | Interleukin 10 | 3586 | 0.024793 | Reported |
| TF | Transferrin | 7018 | 0.026316 | Reported |
| NOS1AP | Nitric oxide synthase 1 adaptor protein | 9722 | 0.027164 | NOT |
| A2M | Alpha−2‐macroglobulin | 2 | 0.030075 | Reported |
| NEK4 | NIMA related kinase 4 | 6787 | 0.033058 | NOT |
| CD86 | CD86 molecule | 942 | 0.033835 | Reported |
| PIK3C2A | Phosphatidylinositol−4‐phosphate 3‐kinase catalytic subunit type 2 alpha | 5286 | 0.041353 | NOT |
| ADAM12 | ADAM metallopeptidase domain 12 | 8038 | 0.044259 | Reported |
| TARBP1 | TAR (HIV−1) RNA binding protein 1 | 6894 | 0.045113 | NOT |
| GABRG2 | Gamma‐aminobutyric acid type A receptor gamma2 subunit | 2566 | 0.048872 | Reported |