Table 3.

Functional connectivity between insula and other voxels in the brain

Region name	X	Y	Z	Voxels	Z‐score	P uncorr
Oxycodone < placebo
Opercular cortex, right	58	−10	12	1944	4.04	<0.001
Postcentral gyrus, left	−40	−24	40	676	3.65	0.001
Superior temporal gyrus, right	−70	−30	2	587	3.53	0.001
Precentral gyrus, left	−40	−18	58	227	3.15	0.030
Oxycodone > placebo	NS
Venlafaxine < placebo
Postcentral gyrus, left	−52	−28	44	877	5.03	<0.001
Venlafaxine > placebo
Thalamus	6	−16	10	475	4.29	0.003
Cerebellum	24	−54	−48	549	3.68	0.001
Brain stem	8	−14	−18	225	3.60	0.026
Cerebellum	18	−86	−52	424	3.54	0.004

NS, nonsignificant.