Table 2.

Cardiac‐related outcomes in acromegalic patients 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54

Author (Year)	PMID	No. of Patients	Statistically Significant Differences (Compared to Controls)
Iida et al (1990)	2145456	8	↑: LV mass (n = 8); end‐diastolic diameter (n = 5), concentric LV hypertrophy (n = 3), normal fractional shortening of LV (n = 7)
Mercuro et al (2000)	11022178	18	↑: LV mass, isovolumetric relaxation time; unchanged EF
Twardowski et al (2001)	11926140	28	↑: LV mass; ventricular premature complexes (n = 18), ventricular filling dysfunction (n = 25), increased frequency of ectopic beats, normal LV ejection fraction
Damjanovic et al (2002)	12034409	102	↑: LV mass; heart failure (n = 10)
Herrmann et al (2002)	12030909	13	↓: Early diastolic annular velocity
Vianna et al (2002)	12040351	15	↑: LV mass, relative wall thickness; diastolic dysfunction
Galderisi et al (2006)	16584510	30	↑: LV mass; diastolic dysfunction (impaired Doppler indexes of LV and RV diastolic function without any difference in global systolic function)
Colao et al (2007)	17646725	57	↑: LV mass, lipid levels, insulin levels
van der Klaauw et al (2008)	18495693	37	↑: Aortic root diameter
Kiris et al (2013)	23254835	30	↑: Left ventricular dyssynchrony
Unubol et al (2014)	24901024	28	↑: Aortic pulse wave velocity, mean platelet volume
Guo et al (2015)	26600803	108	↑: LV end‐diastolic and end‐systolic diameter, myocardial thickness, great vessel diameter; diastolic dysfunction, unchanged systolic function
Orosz et al (2015)	25915951	30	↑: LV mass, relative wall thickness; short‐term beat‐to‐beat QT variability
Sanchez‐Ortiga et al (2015)	26122359	32	↑: LV mass; diastolic dysfunction, sleep apnea‐hypopnea syndrome (n = 26)

Abbreviations: ↑ or ↓, variable that increased or decreased in measurement; LV, left ventricle; n, number of patients; RV, right ventricle.