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. 2019 Apr 17;12:2891–2902. doi: 10.2147/OTT.S201228

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© 2019 Liu et al.

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Effects of Nr5a2 on growth and metastasis of gastric cancer (GC) cells in vivo. (A) Subcutaneous xenograft assay was performed to assess the proliferation potential of control (left flank) and Nr5a2 downregulated AGS cells (right flank) in vivo. An image of subcutaneous tumors from the control and shNr5a2 groups is shown. (B) Tumor volumes were measured on the indicated days, and tumor growth curves were drawn. The data points represent the mean tumor volumes ± SD. (C) Tumor cell tail vein injection was performed to assess the effect of Nr5a2 knockdown on GC cell metastasis in vivo. This representative image shows the metastatic foci on the lung surfaces of mice after tail vein injection. H&E staining of the lung slices shows that Nr5a2 knockdown in AGS cells decreased the metastatic capacity in vivo. The number of metastatic tumor foci was counted in the control and shNr5a2 groups. The data express the mean ± SD from triplicate measurements. *P<0.05. NC, negative control.