Figure 4.

Suppressive effect of ImK on T‐cell infiltration and inflammatory cytokine production in the CNS of the Experimental autoimmune encephalomyelitis group. CD3⁺ cell infiltration (A) was displayed in the white matter of lumbar spinal cord (n = 8, *P < 0.05). Double‐fluorescent immunostaining demonstrated CD3⁺Kv1.3⁺ cells (arrowheads) (B,C) infiltration in lesions (n = 6, *P < 0.05). The concentrations of IL‐2 (D) and IFN‐γ (E) in CSF were measured using ELISA (n = 6, *P < 0.05, ***P < 0.001)