Table 2.
HRs (95% CIs) for AF by quartiles of blood lipids
| Quartiles of TC | Q1, <165 mg/dL | Q2, 165–190 mg/dL | Q3, 190–215 mg/dL | Q4, >215 mg/dL | P for Trend |
|---|---|---|---|---|---|
| AF cases | 92 | 91 | 77 | 68 | |
| Person‐years | 159 074 | 159 186 | 157 469 | 156 538 | |
| AF incidencea | 0.57 | 0.57 | 0.49 | 0.43 | |
| Model 1 | 1 (ref) | 0.93 (0.70‐1.24) | 0.80 (0.59‐1.08) | 0.66 (0.48‐0.90) | 0.006 |
| Model 2 | 1 (ref) | 0.93 (0.69‐1.26) | 0.78 (0.57‐1.07) | 0.60 (0.43‐0.84) | 0.001 |
| Sensitivity analysis | |||||
| Model 3 | 1 (ref) | 0.94 (0.69‐1.27) | 0.76 (0.56‐1.05) | 0.59 (0.42‐0.83) | 0.001 |
| Model 4 | 1 (ref) | 0.99 (0.73‐1.35) | 0.80 (0.58‐1.11) | 0.62 (0.44‐0.87) | 0.003 |
| Model 5 | 1 (ref) | 0.99 (0.73‐1.34) | 0.82 (0.60‐1.13) | 0.64 (0.46‐0.89) | 0.004 |
| Quartiles of LDL‐C | Q1, <71 mg/dL | Q2, 71–90 mg/dL | Q3, 90–110 mg/dL | Q4, >110 mg/dL | P for Trend |
|---|---|---|---|---|---|
| AF cases | 111 | 86 | 69 | 62 | |
| Person‐years | 155 898 | 160 511 | 162 232 | 153 625 | |
| AF incidencea | 0.71 | 0.54 | 0.43 | 0.40 | |
| Model 1 | 1 (ref) | 0.93 (0.70‐1.23) | 0.77 (0.57‐1.05) | 0.65 (0.48‐0.89) | 0.004 |
| Model 2 | 1 (ref) | 0.87 (0.65‐1.17) | 0.77 (0.56‐1.04) | 0.60 (0.43‐0.83) | 0.001 |
| Sensitivity analysis | |||||
| Model 3 | 1 (ref) | 0.87 (0.64‐1.18) | 0.77 (0.56‐1.07) | 0.63 (0.45‐0.88) | 0.005 |
| Model 4 | 1 (ref) | 0.85 (0.63‐1.15) | 0.76 (0.55‐1.05) | 0.59 (0.42‐0.82) | 0.002 |
| Model 5 | 1 (ref) | 0.86 (0.64‐1.16) | 0.79 (0.58‐1.08) | 0.59 (0.43‐0.83) | 0.002 |
| Quartiles of HDL‐C | Q1, <50 mg/dL | Q2, 50–58 mg/dL | Q3, 58–68 mg/dL | Q4, >68 mg/dL | P for Trend |
|---|---|---|---|---|---|
| AF cases | 77 | 81 | 87 | 83 | |
| Person‐years | 152 593 | 162 273 | 159 104 | 158 297 | |
| AF incidencea | 0.50 | 0.50 | 0.55 | 0.52 | |
| Model 1 | 1 (ref) | 0.98 (0.71‐1.33) | 1.06 (0.78‐1.44) | 0.82 (0.60‐1.13) | 0.300 |
| Model 2 | 1 (ref) | 1.05 (0.77‐1.45) | 1.09 (0.79‐1.51) | 0.93 (0.67‐1.29) | 0.721 |
| Sensitivity analysis | |||||
| Model 3 | 1 (ref) | 1.07 (0.78‐1.49) | 1.09 (0.79‐1.52) | 0.91 (0.65‐1.28) | 0.614 |
| Model 4 | 1 (ref) | 1.11 (0.80‐1.55) | 1.13 (0.81‐1.58) | 0.96 (0.68‐1.35) | 0.821 |
| Model 5 | 1 (ref) | 1.10 (0.79‐1.52) | 1.13 (0.81‐1.56) | 0.99 (0.71‐1.38) | 0.958 |
| Quartiles of TG | Q1, <80 mg/dL | Q2, 80–112 mg/dL | Q3, 112–172 mg/dL | Q4, >172 mg/dL | P for Trend |
|---|---|---|---|---|---|
| AF cases | 75 | 69 | 91 | 93 | |
| Person‐years | 157 028 | 159 682 | 156 839 | 158 717 | |
| AF incidencea | 0.48 | 0.43 | 0.58 | 0.59 | |
| Model 1 | 1 (ref) | 0.84 (0.60‐1.16) | 1.11 (0.82‐1.50) | 1.21 (0.89‐1.64) | 0.082 |
| Model 2 | 1 (ref) | 0.73 (0.52‐1.03) | 0.86 (0.62‐1.19) | 0.87 (0.62‐1.21) | 0.716 |
| Sensitivity analysis | |||||
| Model 3 | 1 (ref) | 0.70 (0.50‐0.99) | 0.84 (0.60‐1.17) | 0.82 (0.59‐1.15) | 0.513 |
| Model 4 | 1 (ref) | 0.74 (0.52‐1.04) | 0.85 (0.61‐1.19) | 0.86 (0.61‐1.22) | 0.676 |
| Model 5 | 1 (ref) | 0.76 (0.53‐1.05) | 0.84 (0.60‐1.16) | 0.87 (0.62‐1.22) | 0.674 |
Abbreviations: AF, atrial fibrillation; BMI, body mass index; CI, confidence interval; DBP, diastolic blood pressure; DM, diabetes mellitus; HDL‐C, high density‐lipoprotein cholesterol; HR, hazard ratio; hs‐CRP, high‐sensitivity C‐reactive protein; LDL‐C, low density‐lipoprotein cholesterol; MI, myocardial infarction; Q, quartile; ref, reference; SBP, systolic blood pressure; SUA, serum uric acid; TC, total cholesterol; TG, triglycerides.
Model 1 adjusted for sex and age. Model 2 adjusted for sex, age, education, income, smoking, alcohol use, SBP, DBP, BMI, height, physical activity, hs‐CRP, SUA, DM, antihypertensive drugs, snoring. Model 3 adjusted for model 2 and further excluded MI at baseline (eligible participants: 87 744, with 316 cases of incident AF). Model 4 adjusted for model 2 and further excluded cerebral infarction at baseline (eligible participants: 87 187, with 310 cases of incident AF). Model 5 adjusted for model 2 and further excluded lipid‐lowering drugs at baseline (eligible participants: 87 951, with 321 cases of incident AF).
Per 1000 person‐years.