Table 1.

Inclusion and exclusion criteria

Inclusion criteria
Patient age > 18 y
Diagnosis of ARVD based on Task Force criteria. Two major criteria: 1 morphologic and 1 rhythmic, or 1 major and 2 minor criteria19, 20
Increased RV volume (>100 mL/m2 female, >110 mL/m2 male)
Genetic analysis performed for desmosome genes (PKP2, DSG2, DSC2, DSP, JUP) whatever the result, mutation or no mutation
LVEF >40%
Exclusion criteria
Pregnancy
No health insurance
MRI contraindication (claustrophobia, implantable defibrillator)
No genetic analysis for desmosome genes
Right HF, defined with symptoms (exertional dyspnea, ankle swelling, epigastric fullness and right upper abdominal discomfort or pain) and signs (raised jugular venous pulse, an accentuated second pulmonary sound, RV gallop, an enlarged tender liver)
Ramipril contraindication (hypotension, renal failure)
Normal RV volume
Heart transplantation
Swallowing disorders

Abbreviations: ARVD, arrhythmogenic right ventricular dysplasia; HF, heart failure; LVEF, left ventricular ejection fraction; MRI, magnetic resonance imaging; RV, right ventricular.