Figure 2.
Schematic representation of striatal local circuits highlighting alterations of inhibitory currents and GABAAR subunit expression in identified neurons in mouse models of HD. The striatum includes medium‐sized output neurons expressing dopamine D1 or D2 receptors, and fast‐spiking, persistent low‐threshold spiking, or tonically active interneurons. The 2 main projection pathways to the external globus pallidus and substantia nigra pars reticulata/internal globus pallidus are also indicated. Alteration of inhibitory currents in symptomatic HD mice is indicated by thicker (increase) or thinner (decrease) lines. Alteration in subunit expression or tonic inhibition is indicated by↑, increase; ↓, decrease; or =, no change. The figure was constructed using data from30, 66, 69, 80, 101