Figure 1.

Rats on day 15 after the STZ injection exhibited poor performance in the learning and memory trials. In the MWM, STZ‐injected rats exhibited a longer escape latency (A) to reach the hidden platform during acquisition training. The escape latencies to find the platform during 5 d of hidden platform trials (HD 1‐5) and visible platform trials (VD 1‐3) were analyzed using repeated‐measures ANOVA (group × day), followed by Tukey's multiple comparison post hoc test. The time spent in target quadrant during the probe trial (B) was compared using one‐way ANOVA followed by Tukey's multiple comparison post hoc test. The data are expressed as mean ± SEM (n = 8‐10 per group). **P < 0.01, vs vehicle group