STZ‐injected rats exhibited an increase in wakefulness and decrease in sleep. Sleep parameters included hourly time courses of wakefulness. A, The photomicrograph of representative cannula placement for i.c.v. injection. B, Time spent in wakefulness (W), nonrapid eye movement sleep (NREMS), light sleep (LS), slow‐wave sleep (SWS), and rapid eye movement sleep (REMS), percentage of REMS/LS/SWS relative to total sleep (REMS%, SWS%, LS%). C, D, Bouts and mean duration of W, NREMS, LS, SWS, and REMS episodes. E, F, Sleep latency and REM sleep latency. G, Time spent in sleep per 1 h. The data are expressed as mean ± SEM (n = 8‐10 per group). *P < 0.05 and **P < 0.01 vs vehicle (Student‐Newman‐Keuls test)