Figure 2.

Dysconnectivity and depression. Four networks including the affective network (AN), reward network (RN), default mode network (DMN), and cognitive control network (CCN) have been mainly associated with the neural substrates of depression, with hyperconnectivity (marked in red) of the AN and DMN and attenuated connectivity (marked in green) of the RN and CCN observed in the patients. OFC: orbitofrontal cortex; INS: insula; AMY: amygdala; HIP: hippocampus; vACC: ventral anterior cingulate cortex; mPFC: medial prefrontal cortex; PCC: posterior cingulate cortex; PCUN: precuneus; ANG: Angular; DLPFC: dorsolateral prefrontal cortex; dACC: dorsal anterior cingulate cortex; PFC: prefrontal cortex; CAU: caudate; NA: nucleus accumbens. This figure was prepared with the BrainNet Viewer132