Table 2.
Main Clinical Characteristics of Patients With NASH‐Related HCC Compared With Other Causative Factors
| Author, Year, Publication | Study Population | Age (years) | Diabetes | Dyslipidemia | Hypertension | BMI (kg/m2) | Cirrhosis | Tumor Burden at Diagnosis | ||
|---|---|---|---|---|---|---|---|---|---|---|
| No. of Nodules | Size (cm) | |||||||||
| Dyson J, 2014, J Hepatol5 | 136 NAFLD/NASH | 71 | 80% | NR | NR | 32 | 77% | 2.3 | 5.3 | |
| 469 other causative factors | 68.2 | 30% | 26.4 | 70.9% | 2.4 | 5.7 | ||||
| Beste L, 2015, Gastroenterology19 | 1029 NAFLD/NASH | 70.5 | 76% | NR | NR | 31 | NR | NR | ||
| 6641 other causative factors | 66.2 | 39.2% | 28.2 | |||||||
| BCLC | ||||||||||
| 0‐A | B | C | ||||||||
| Piscaglia F, 2016, Hepatology20 | 145 NAFLD/NASH | 67.8 | 73.1% | 57% | 73.1% | 29.1 | 53.8% | 42.8% | 19.3% | 33.1% |
| 611 HCV | 71.1 | 24.9% | 8.3% | 37.1% | 27.6 | 97.2% | 53% | 14.6% | 23.9% | |
| BCLC | ||||||||||
| A | B | C | ||||||||
| Weinmann A, 2015, BMC Cancer21 | 45 NAFLD/NASH | 67.6 | 66.7% | 0% | 71.1% | 29 | 77.8% | 20% | 24.4% | 42.2% |
| 1074 other causative factors | 65 | 37.8% | 19.6% | 45.2% | 26.6 | 79.9% | 24% | 16.7% | 42.6% | |
| Wong RJ, 2014, Hepatology22 | 807 NAFLD/NASH | 59.3 | 42.8% | NR | NR | 33.6 | NR | NR | ||
| 7066 other causative factors | 57.2 | 20.8% | 27.3 | |||||||
| >3 Nodules | Size (cm) | Vascular inv. or Metastasis | ||||||||
| Tateishi R, 2015, J Gastroenterol23 | 596 NAFLD/NASH | 69.7 | 32.7% | 22.9% | 55.5% | NR | 64.9% | 16.8% | 3.0 | 6% |
| 4730 other causative factors | 72 | 41.9% | 12.5% | 36.9% | 63.4% | 23% | 3.06 | 11.6% | ||
Abbreviations: BCLC, Barcelona Clinic Liver Cancer Staging; BMI, body mass index; NR, not reported.