Table 4.

Torque Teno Virus Levels Stratified According to Baseline Characteristics

Characteristics	TTV Copies/mL (IQR)		P Value
	Variable Positivea	Variable Negativea
Recipient data
Recipient age >56 yearsb	4.2 × 108 (1.8 × 107–2.9 × 109)	3.2 × 107 (3.6 × 106–4.0 × 108)	.050
Recipient female	9.3 × 106 (1.8 × 106–3.4 × 108)	3.4 × 108 (1.8 × 107–2.4 × 109)	.021
Recipient BMI >26 kg/m2 b	4.2 × 108 (3.4 × 106–1.7 × 109)	6.8 × 107 (8.3 × 106–4.2 × 108)	.629
Renal replacement therapy >2.6 yearsb, c	5.2 × 107 (5.3 × 106–8.3 × 108)	1.8 × 108 (3.3 × 106–2.7 × 109)	.589
Diabetes mellitus	1.7 × 107 (2.8 × 106–4.3 × 108)	1.8 × 108 (5.0 × 106–1.5 × 109)	.243
Major comorbidityd	5.2 × 107 (4.0 × 106–1.5 × 109)	1.4 × 108 (3.9 × 106–1.1 × 109)	.978
CMV IgG positive	2.9 × 107 (3.4 × 106–5.3 × 109)	4.3 × 108 (1.8 × 108–2.9 × 109)	.003
EBV IgG positive	7.6 × 107 (4.1 × 106–1.4 × 109)	3.8 × 108 (3.5 × 108–NA)	.415
HBc antibody positive	7.3 × 106 (3.6 × 106–1.4 × 108)	2.6 × 108 (8.0 × 106–1.7 × 109)	.074
HIV antibody/antigen positive	NA	NA	.366
Donor data
Living donor	9.9 × 107 (1.2 × 107–4.3 × 108)	1.8 × 108 (4.1 × 106–1.4 × 109)	.884
Donor after circulatory death	1.7 × 108 (1.6 × 105–7.6 × 108)	2.4 × 108 (7.3 × 106–1.8 × 109)	.203
Donor age >56 yearsb	4.2 × 108 (9.3 × 106–2.9 × 109)	3.0 × 107 (3.8 × 106–4.2 × 108)	.014
Donor female	3.1 × 107 (3.9 × 106–1.6 × 109)	2.2 × 108 (7.2 × 106–1.0 × 109)	.699
Donor CMV IgG positive	3.4 × 107 (3.8 × 106–2.1 × 109)	4.2 × 108 (1.1 × 107–1.6 × 109)	.164
Transplant data
Retransplantation	1.0 × 107 (9.9 × 105–3.3 × 108)	2.6 × 108 (9.3 × 106–1.7 × 109)	.041
ABO incompatible transplantation	1.0 × 106 (6.3 × 105–1.8 × 109)	1.8 × 108 (7.3 × 106–1.3 × 109)	.633
Donor specific antibody	2.5 × 107 (1.8 × 106–2.1 × 108)	1.8 × 108 (5.3 × 106–1.4 × 109)	.238
HLA A, B, DR mismatch >3b	4.7 × 107 (2.8 × 106–1.3 × 109)	1.8 × 108 (7.3 × 106–1.3 × 109)	.486
ATG induction	1.9 × 107 (2.3 × 106–1.5 × 108)	1.8 × 108 (5.2 × 106–1.5 × 109)	.193
CMV prophylaxis	4.0 × 108 (4.0 × 107–1.8 × 109)	3.1 × 107 (3.7 × 106–1.2 × 109)	.067

Mann-Whitney U test was used for comparing continuous data and group comparisons were made using the Χ² test. Exact tests were used where applicable.

Abbreviations: ATG, antithymoglobulin; BMI, body mass index; CMV, cytomegalovirus; EBV, Epstein Barr virus; HBc, hepatitis B-core antigen; HIV, human immunodeficiency virus; HLA, human leukocyte antigen; IgG immunoglobulin G; IQR, inter quartile range; NA, not applicable; TTV, torque teno virus.

^aTTV levels preceding the first documented event (infection or no infection) per patient were analyzed.

^bCutoff defined by median.

^cTime between the start of renal replacement therapy and transplantation.

^dAny history of major cardiovascular, gastrointestinal, pulmonary, or malignant disease.