Table 5.

TTV Levels Stratified According to Clinical Characteristics at the Time of Assessment

Characteristics	TTV Copies/mL (IQR)		P Value
	Variable Positive	Variable Negative
Clinical data
Infection	1.3 × 108 (1.3 × 107–8.6 × 108)	9.9 × 107 (2.5 × 106–1.4 × 109)	.953
Allograft rejectiona	5.2 × 107 (1.3 × 106–5.9 × 108)	1.7 × 108 (3.4 × 106–1.7 × 109)	.370
Antiviral treatment	NA	9.9 × 107 (2.5 × 106–1.1 × 109)	>.99
Diabetes mellitus	4.3 × 107 (2.6 × 106–8.8 × 108)	1.5 × 108 (2.7 × 106–1.4 × 109)	.806
Laboratory data
CMV PCR positive	3.8 × 108 (2.5 × 107–2.8 × 109)	3.4 × 107 (1.3 × 106–8.5 × 108)	.014
Leukocytes > 6.6 g/Lb	1.7 × 108 (3.4 × 106–1.1 × 109)	5.2 × 107 (2.4 × 106–1.2 × 109)	.841
Neutrophiles > 4.5 g/Lb	3.5 × 107 (1.9 × 106–5.4 × 108)	2.4 × 107 (4.0 × 105–4.2 × 108)	.896
Lymphocytes > 1.3 g/Lb	4.4 × 106 (2.4 × 105–1.8 × 108)	2.6 × 108 (1.2 × 107–1.3 × 109)	<.001
eGFR > 48 mL/min/m2; c	3.0 × 107 (1.3 × 106–6.4 × 108)	3.1 × 108 (3.9 × 106–1.8 × 109)	.069
Urinary protein/creatinine ratio >192 mg/mgb	5.2 × 107 (2.9 × 106–9.6 × 108)	3.0 × 108 (6.9 × 105–2.5 × 109)	.776
CRP >0.3 mg/dLb	3.6 × 107 (2.4 × 106–6.4 × 108)	3.7 × 108 (3.4 × 106–2.5 × 109)	.080
Immunosuppression
Prednisolone >5 mgb	1.7 × 108 (1.1 × 107–8.9 × 108)	9.9 × 107 (1.3 × 106–1.4 × 109)	.584
Cyclosporine	1.2 × 107 (2.0 × 105–9.2 × 108)	1.5 × 108 (3.4 × 106–1.2 × 109)	.290
Tacrolimus	1.1 × 108 (3.4 × 106–1.3 × 109)	1.0 × 108 (2.3 × 106–8.7 × 108)	.575
Tacrolimus trough level >7.3 ng/mLb	1.8 × 108 (2.2 × 106–1.9 × 109)	5.1 × 107 (3.5 × 106–8.8 × 108)	.585
Tacrolimus once per day	3.8 × 108 (3.8 × 106–3.4 × 109)	4.9 × 107 (2.0 × 106–8.5 × 108)	.098
Everolimus	1.8 × 107 (7.6 × 103 – NA)	1.3 × 108 (2.9 × 106 – 1.2 × 109)	.307
Belatacept	7.2 × 108 (1.0 × 108 – 1.8 × 109)	7.5 × 107 (2.3 × 106–1.1 × 109)	.263
Mycophenolic acid	1.5 × 108 (3.3 × 106–1.3 × 109)	1.8 × 107 (7.6 × 103 – NA)	.299
Mycophenolic acid > 1.5 gb	2.6 × 107 (1.8 × 107–9.6 × 108)	1.8 × 107 (4.8 × 105–1.3 × 109)	.040

Mann-Whitney U test was used for comparing continuous data and group comparisons were made using the Χ² test. Exact tests were used where applicable.

Abbreviations: CMV, cytomegalovirus; CRP, C reactive protein; eGFR, estimated glomerular filtration rate; IQR, interquartile range; NA, not applicable; PCR polymerase chain reaction; TTV, torque teno virus.

^aAny episode of biopsy-proven allograft rejection or antirejection therapy preceding torque teno virus assessment.

^bCutoff defined by median.

^c eGFR was calculated using the Mayo equation [20].