Table 4.
Association of haplotypes within MAPK1, HIF‐1α, and HO‐1 with Gensini scores
| Group | Haplotype | Frequency | χ2 Test | OR (95% CI) | P Value | |
|---|---|---|---|---|---|---|
| ≤34 | >34 | |||||
| Pre‐CAD | C‐G‐A‐T‐C‐A‐S | 4 (0.03) | 2 (0.04) | 0.30 | 0.62 (0.11‐3.51) | 0.58 |
| C‐G‐A‐T‐C‐A‐L | 4 (0.03) | 1 (0.03) | 0.04 | 1.27 (0.14‐11.69) | 0.83 | |
| Post‐CAD | C‐G‐A‐T‐C‐A‐L | 9 (0.04) | 9 (8.67) | 0.00 | 1.00 (0.39‐2.57) | 0.87 |
| G‐G‐A‐T‐C‐A‐S | 7 (0.03) | 11 (11.05) | 0.93 | 0.62 (0.24‐1.64) | 0.34 | |
| G‐G‐A‐T‐C‐A‐L | 10 (0.04) | 12 (0.05) | 0.19 | 0.83 (0.35‐1.95) | 0.66 | |
| G‐G‐A‐T‐C‐T‐L | 8 (0.04) | 9 (0.04) | 0.06 | 0.88 (0.34‐2.34) | 0.81 | |
Abbreviations: CAD, coronary artery disease; CI, confidence interval; HIF‐1α, hypoxia inducible factor‐1α; HO‐1, heme oxygenase‐1; MAPK1, mitogen activated protein kinase‐1; OR, odds ratio; post‐CAD, postmenopausal CAD; pre‐CAD, premenopausal CAD.