Table 1.

Inclusion and exclusion criteria

Inclusion Criteria	Exclusion Criteria
Age ≥ 65 y	Presence of any condition or circumstance that, in the opinion of the investigator, could significantly limit the complete follow‐up of the patient (eg, tourist, non‐native speaker or does not understand the local language where interpreter services are not reliably available, psychiatric disturbances, alcohol or drug abuse)
DM requiring medication	Presence of serious/severe comorbidities that, in the opinion of the investigator, may limit life expectancy to <1 y
Documented history of a second prior presumed spontaneous MI (>1 y ago)	Current participation in a blinded RCT
Documented history of angiographic evidence of multivessel CAD	Patients receiving treatment with ticagrelor beyond 12 months, or off‐label use of ticagrelor
Chronic, non–end‐stage renal dysfunction (CrCl ≥15 mL/min and <60 mL/min, calculated by Cockcroft‐Gault equation)

Abbreviations: CAD, coronary artery disease; CrCl, creatinine clearance; DM, diabetes mellitus; MI, myocardial infarction; RCT, randomized clinical trial.