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Heterogeneity Within Each NYHA Class
| NYHA Class | No. of Studies | No. of Patients | Pooled Average 6MWD, m (95% CI) | I 2, % | Q | P Value |
|---|---|---|---|---|---|---|
| I | 16 | 984 | 420 (379 to 462) | 98.4 | 934.2 | <0.0001 |
| II | 24 | 2769 | 393 (362 to 424) | 98.6 | 1657.6 | <0.0001 |
| III | 29 | 1530 | 325 (296 to 354) | 97.1 | 964.0 | <0.0001 |
| IV | 7 | 139 | 225 (115 to 336) | 97.6 | 248.4 | <0.0001 |
| Overall | 35 | 5422 | 358 (338 to 379) | 98.7 | 5580.1 | <0.0001 |
Abbreviations: 6MWD, 6‐minute walk distance; CI, confidence interval; NYHA, New York Heart Association.
