Table 1. Putative eSNPs in LD with trait-associated GWAS SNPs.
Chr | eSNP | GWAS SNP | r2 | Trait(s) | p-value | Reported Causal Gene(s) | Nearest Gene(s) | Reference(s) |
---|---|---|---|---|---|---|---|---|
1 | rs17315646 | rs10489615 | 0.97 | HDL | 4x10-9 | GALNT2 | GALNT2 | [6] |
rs2144300 | 1 | HDL | 3x10-14 | [2] | ||||
TG | 8x10-7 | [2] | ||||||
rs4846914 | 1 | HDL | 2x10-13 | [1],[4] | ||||
TG | 7x10-15 | [1] | ||||||
9 | rs2575875 | rs4149268 | 0.96 | HDL | 1x10-10 | ABCA1 | ABCA1 | [2] |
9 |
rs3847301 |
rs3890182 | 0.81 | HDL | 3x10-10 | ABCA1 | ABCA1 | [1],[6] |
rs3905000 | 0.81 | HDL | 9x10-13 | [3] | ||||
9 | rs643531 | rs643531 | 1 | HDL | 7x10-9 | TTC39B | TTC39B | [6] |
11 | rs12287066 | rs12272004 | 0.83 | TC | 7x10-7 | APOA1-C3-A4-A5 | APOA5 | [3] |
LDL | 5x10-13 | [3] | ||||||
TG | 5x10-13 | [3] | ||||||
rs12286037 | 1 | TG | 1x10-26 | [2] | ||||
rs28927680 | 1 | TG | 2x10-17 | [1] | ||||
16 | rs1109166 | rs12449157 | 0.94 | HDL | 2x10-7 | GFOD2, LCAT | LCAT, SLC12A4 | [6] |
19 | rs2075650 | rs2075650 | 1 | TC | 3x10-19 | TOMM4, APOE | TOMM4, APOE | [3] |
r2 is based on HapMap CEU.p-values from the original GWAS studies.