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. 2019 Apr 30;14(4):e0200968. doi: 10.1371/journal.pone.0200968

Fig 1. ADAR2 expression is reduced in CHD patients.

Fig 1

(A) ADAR1 p110 is strongly expressed in brain cerebral hemispheres as compared to left heart ventricle. The Y-axis represented the log10 of the transcript per million (TPM) value. The whiskers represent the maximum and minimum values. The median is represented as a black line in the box. (B) The expression of ADAR1 p150 is strongest in the bladder, followed by the cervix and tibial artery. ADAR1p150 expression is slightly higher in the left heart ventricle as compared to cerebral hemisphere. The whiskers represent the maximum and minimum values. The median is represented as a black line in the box. (C) ADAR2 expression is strongest in the tibial artery, followed by the bladder, stomach aorta and coronary artery. The whiskers represent the maximum and minimum values. The median is represented as a black line in the box. (D) FOXP1 expression is strongest in the aorta, followed by the tibial artery and bladder. The whiskers represent the maximum and minimum values. The median is represented as a black line in the box. (E) Bar graph showing the relative RNA levels of ADAR1, ADAR2 and FOXP1 in patients compared to controls. ADAR2 and FOXP1 showed significantly reduced expression at the RNA level, whereas both isoforms of ADAR1 (ADAR1 p110 (ADAR1c) and p150 (ADAR1i)) showed upregulation in CHD patients. The error bars indicate the mean +/-SD. The statistical significance was determined by the Mann–Whitney U test *P < 0.05 (versus control).