Figure 2.

Neural biomarkers of change in anxiety. A significant three-way interaction between amygdala, VS, and dlPFC activity predicted change in anxiety over time (P = 0.0123, R²-change = 4.1%). Post hoc analyses of the two-way interactions revealed a significant interaction between reward-related VS activity and threat-related amygdala activity leading to changes in anxiety, at low dlPFC activity (bottom; b = –41.65, P < 0.001) or average dlPFC activity (middle; b = –25.15, P = 0.002), but not at high dlPFC activity (top; b = –8.64, P = 0.278).