Table 1.
Baseline characteristics of study participants stratified by computed tomography honeycombing
| Characteristics | CT Honeycombing Absent (n = 838) | CT Honeycombing Present (n = 492) |
|---|---|---|
| Age, yr | 66.1 (13.2) | 68.1 (11.8) |
| Male | 390 (46.5) | 270 (54.9) |
| Race/ethnicity | ||
| White | 636 (75.9) | 373 (75.8) |
| Black | 110 (13.1) | 65 (13.2) |
| Hispanic | 37 (4.4) | 27 (5.5) |
| Asian | 40 (4.8) | 20 (4.1) |
| Ever smoker | 329 (39.7) | 245 (49.8) |
| Body mass index, kg/m2 | 29.8 (6.9) | 28.2 (5.7) |
| Clinical features | ||
| Crackles | 519 (76.7) | 352 (84.0) |
| Clubbing | 74 (8.8) | 87 (17.7) |
| Lung function | ||
| FVC, % predicted | 68.9 (19.4) | 65.9 (18.8) |
| DlCO, % predicted | 52.3 (21.8) | 46.1 (19.6) |
| Oxygen therapy | 228 (27.2) | 172 (35.0) |
| Immunosuppressive therapy | 409 (50.0) | 259 (54.0) |
| CT fibrosis | ||
| Reticulation | 532 (63.5) | 328 (66.7) |
| Traction bronchiectasis | 157 (18.7) | 242 (49.2) |
| Antifibrotic therapy | 63 (7.5) | 38 (7.7) |
| Time from CT to ILD diagnosis, mo | 3.5 (23.1) | 2.6 (24.0) |
| ILD subcategory | ||
| Idiopathic pulmonary fibrosis | 399 (47.6) | 240 (48.8) |
| Connective tissue disease–associated ILD | 154 (18.4) | 111 (22.6) |
| Unclassifiable/others | 202 (24.1) | 81 (16.5) |
| Chronic hypersensitivity pneumonitis | 83 (9.9) | 60 (12.2) |
Definition of abbreviations: CT = computed tomography; DlCO = diffusing capacity of the lung for carbon monoxide; FVC = forced vital capacity; ILD = interstitial lung disease; SD = standard deviation.
Total sample size, N = 1,330. Categorical variables presented as n (%); continuous variables presented as mean (SD). Exception for participants: body mass index, n = 1,247; crackles, n = 1,096; clubbing, n = 1,329; FVC, n = 1,265; DlCO, n = 1,191; immunosuppressive therapy, n = 1,302; idiopathic pulmonary fibrosis, n = 639; connective tissue disease–associated ILD, n = 265; chronic hypersensitivity pneumonitis, n = 143; unclassifiable/other ILD, n = 283.