Table 1.
Demographics and comorbidities of discovery and replication phenome-wide association study populations
| Discovery Cohort (n = 121,530) | Replication Cohort (n = 2,039) | |
|---|---|---|
| Age, mean (SD) | 49.52 (16.70) | 64.46 (11.06) |
| Race, white | 104,468 (86) | 2,039 (100) |
| Male | 48,344 (40) | 937 (46) |
| RDW, median (IQR) | 13.1 (12.7–13.6) | 13.3 (12.8–13.8) |
| Hemoglobin, mean (SD) | 14.32 (1.13) | 14.52 (1.08) |
| Atrial fibrillation | 4,381 (4) | 465 (23) |
| Chronic kidney disease | 1,481 (1) | 76 (4) |
| Chronic obstructive pulmonary disease | 4,664 (4) | 184 (9) |
| Chronic pulmonary heart disease | 965 (1) | 128 (6) |
| Coronary artery disease | 8,212 (7) | 705 (35) |
| Diabetes mellitus | 11,726 (10) | 342 (17) |
| Congestive heart failure | 3,530 (3) | 349 (17) |
| Hypertension | 36,298 (30) | 1,388 (68) |
| Obesity | 13,737 (11) | 352 (17) |
| Pulmonary arterial hypertension | 365 (0.3) | 46 (2) |
Definition of abbreviations: IQR = interquartile range; RDW = red cell distribution width; SD = standard deviation.
Data presented as n (%) unless otherwise noted.